Compound Detail
CHEMBL4060704
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Cc1cc(C)cc(/N=N\c2cccc(C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)B3OC4C[C@@H]5C[C@@H](C5(C)C)[C@]4(C)O3)[C@@H](C)O)c2)c1
Basic Information
| ChEMBL ID | CHEMBL4060704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MTEBSPISGQUSCT-BTTQZBJMSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
602.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.6 | 6.195 | 249.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 249.0 | nM | 6.6 | Inhibition of chymotrypsin-like activity of 20S proteasome in rabbit 20S proteas... | 28642029 |
| Unchecked | IC50 | = | 1633.0 | nM | 5.79 | Inhibition of caspase-like activity of 20S proteasome in rabbit 20S proteasome p... | 28642029 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28642029 | 10.1016/j.bmc.2017.06.011 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine