Compound Detail
CHEMBL4061687
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Basic Information
| ChEMBL ID | CHEMBL4061687 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNEHWKJRRXJZJT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
458.5
MW (Da)
3.79
ALogP
7
HBA
3
HBD
104.4
PSA (Ų)
0.39
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.01 | 7.01 | 97.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 97.4 | nM | 7.01 | Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 min... | 29357250 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29357250 | 10.1021/acs.jmedchem.7b01261 | MV4-11 | 2 |
| 29357250 | 10.1021/acs.jmedchem.7b01261 | CDK2/Cyclin A1 | 2 |
| 29357250 | 10.1021/acs.jmedchem.7b01261 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine