Compound Detail
CHEMBL4062524
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Basic Information
| ChEMBL ID | CHEMBL4062524 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CLGPEEHBYMSIJX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
330.4
MW (Da)
3.01
ALogP
4
HBA
1
HBD
58.6
PSA (Ų)
0.94
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 2 CHEMBL4016 | EC50 | 7.34 | 7.32 | 46.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 2 | EC50 | = | 46.13 | nM | 7.34 | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expres... | 29256599 |
| Glutamate receptor 2 | EC50 | = | 50.0 | nM | 7.3 | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expres... | 29256599 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29256599 | 10.1021/acs.jmedchem.7b01323 | Glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine