Compound Detail
CHEMBL4063142
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N[C@@H](CCP(=O)(O)C(O)c1ccc(C(F)(F)F)c([N+](=O)[O-])c1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL4063142 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGHRXKZPSJWWED-YMNIQAILSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
386.2
MW (Da)
1.68
ALogP
6
HBA
4
HBD
164.0
PSA (Ų)
0.31
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 6.42 | 6.39 | 380.0 | 2 |
| Metabotropic glutamate receptor 8 CHEMBL3228 | EC50 | 5.81 | 5.81 | 1540.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | EC50 | 5.24 | 5.08 | 5700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 380.0 | nM | 6.42 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 4 | EC50 | = | 440.0 | nM | 6.36 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 8 | EC50 | = | 1540.0 | nM | 5.81 | Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 6 | EC50 | = | 5700.0 | nM | 5.24 | Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 6 | EC50 | = | 11900.0 | nM | 4.92 | Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 6 | 2 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 4 | 2 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 7 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 8 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine