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Compound Detail

CHEMBL4070793

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BrCCCc1ccc(-c2ccc(-c3ccc(CCCBr)s3)s2)s1

Basic Information

ChEMBL ID CHEMBL4070793
Phase Preclinical
Structure Type MOL
InChI Key XAQRACBPPWQYPT-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

490.4
MW (Da)
7.86
ALogP
3
HBA
0
HBD
0.0
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H18Br2S3
MW 490.35
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -0.35

Activity Summary

IC50 1 meas. best 5.18

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.18 5.18 6641.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 6641.0 nM 5.18 Inhibition of Influenza A virus (A/Thailand/Kan353/2004(H5N1)) hemagglutinin exp... 28246043

Literature References

PubMed DOI Target Context # Activities
28246043 10.1016/j.ejmech.2017.02.040 Unchecked 1
28246043 10.1016/j.ejmech.2017.02.040 MDCK 1

Data from ChEMBL 36 via Core Engine