Compound Detail
CHEMBL4071410
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Basic Information
| ChEMBL ID | CHEMBL4071410 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BGPQOVRSQPXNFD-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
326.4
MW (Da)
2.76
ALogP
3
HBA
2
HBD
74.3
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 3 CHEMBL5891 | IC50 | 7.66 | 7.265 | 22.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 3 | IC50 | = | 22.0 | nM | 7.66 | Inhibition of PRMT3 (unknown origin) using C-terminally biotinylated histone H4 ... | 29244490 |
| Protein arginine N-methyltransferase 3 | IC50 | = | 134.0 | nM | 6.87 | Inhibition of FLAG-tagged wild type human PRMT3 expressed in HEK293 cells assess... | 29244490 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29244490 | 10.1021/acs.jmedchem.7b01674 | Protein arginine N-methyltransferase 3 | 2 |
Data from ChEMBL 36 via Core Engine