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Compound Detail

CHEMBL407308

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c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2

Basic Information

ChEMBL ID CHEMBL407308
Phase Preclinical
Structure Type MOL
InChI Key MWTDIAXAEKTMKO-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

251.3
MW (Da)
3.14
ALogP
3
HBA
1
HBD
54.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H13N3O
MW 251.29
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness -0.07

Activity Summary

EC50 2 meas. best 6.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
EC50 6.77 6.77 170.0 1
Alpha-1D adrenergic receptor
CHEMBL223
EC50 5.86 5.86 1390.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18400496 10.1016/j.bmcl.2008.03.070 Alpha-1A adrenergic receptor 2
18400496 10.1016/j.bmcl.2008.03.070 Alpha-1D adrenergic receptor 2
18400496 10.1016/j.bmcl.2008.03.070 Alpha-1B adrenergic receptor 1
18400496 10.1016/j.bmcl.2008.03.070 Alpha-2A adrenergic receptor 1

Data from ChEMBL 36 via Core Engine