Compound Detail
CHEMBL4073701
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C[C@@H]1CN(c2c(NC(=O)c3cccc(-c4ccccn4)c3)cccc2C(F)(F)F)C[C@H](C)O1
Basic Information
| ChEMBL ID | CHEMBL4073701 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KHTDNEVIFXQOKO-CALCHBBNSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
2
Publications
0
Known Names
Molecular Properties
455.5
MW (Da)
5.63
ALogP
4
HBA
1
HBD
54.5
PSA (Ų)
0.55
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 79.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 223.0 | mL.min-1.g-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of slow inactivated human NaV1.7 expressed in HEK293 cells at -20 mV ... | 28684121 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28684121 | 10.1016/j.bmcl.2017.06.054 | Liver | 2 |
| 28684121 | 10.1016/j.bmcl.2017.06.054 | Sodium channel protein type 9 subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine