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Compound Detail

CHEMBL4075768

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OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3[nH]ccc3c2)c1)c1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4075768
Phase Preclinical
Structure Type MOL
InChI Key DOJMMERTORDDRM-VWLOTQADSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

455.9
MW (Da)
6.40
ALogP
4
HBA
4
HBD
81.2
PSA (Ų)
0.24
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H22ClN3O2
MW 455.95
Aromatic Rings 5
Heavy Atoms 33
NP-Likeness -0.54

Literature References

PubMed DOI Target Context # Activities
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 2 1
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 1 1
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 3 1

Data from ChEMBL 36 via Core Engine