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Compound Detail

CHEMBL4077606

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C[C@]12C[C@@H](O)[C@H]3[C@@H](CC[C@]4(O)C[C@@H](O)C[C@@H](O)[C@]34CO)[C@@]1(O)CC[C@@H]2c1cn(Cc2ccc(Cl)cc2)nn1

Basic Information

ChEMBL ID CHEMBL4077606
Phase Preclinical
Structure Type MOL
InChI Key JRXGLBPLOHQBSY-HTXMBPOHSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

548.1
MW (Da)
1.61
ALogP
9
HBA
6
HBD
152.1
PSA (Ų)
0.34
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H38ClN3O6
MW 548.08
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness 1.38

Activity Summary

IC50 1 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
N+/K+ ATPase alpha-4/beta-1
CHEMBL4106165
IC50 7.5 7.5 32.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29291372 10.1021/acs.jmedchem.7b00925 N+/K+ ATPase alpha-4/beta-1 1

Data from ChEMBL 36 via Core Engine