Compound Detail
CHEMBL4081928
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Basic Information
| ChEMBL ID | CHEMBL4081928 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MGXMSHAYYGXJLQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
278.4
MW (Da)
1.27
ALogP
3
HBA
2
HBD
78.1
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5A CHEMBL2424504 | IC50 | 9.59 | 8.095 | 0.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5A | IC50 | = | 0.26 | nM | 9.59 | KDM5 Enzyme Assay: Full length KDM5A enzyme was expressed and purified inhouse. ... | - |
| Lysine-specific demethylase 5A | IC50 | = | 251.0 | nM | 6.6 | Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculo... | 28512031 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28512031 | 10.1016/j.bmcl.2017.05.016 | Lysine-specific demethylase 5A | 2 |
Data from ChEMBL 36 via Core Engine