Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL408504

TYROCIDINE A
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL408504
Name TYROCIDINE A
Phase Preclinical
Structure Type BOTH
InChI Key GSXRBRIWJGAPDU-BBVRJQLQSA-N
2
Targets
3
Activities
1
Assay Types
1
PK Parameters
20
Publications
0
Known Names

Molecular Properties

1270.5
MW (Da)

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C66H87N13O13
MW 1270.50

Activity Summary

IC50 3 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Listeria monocytogenes
CHEMBL614974
 IC50 5.0 4.945 9900.0 2
Micrococcus luteus
CHEMBL614421
 IC50 4.66 4.66 22000.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 0.5383 hr Listeria monocytogenes

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Listeria monocytogenes IC50 = 9900.0 nM 5.0 Antibacterial activity against leucocin A-resistant Listeria monocytogenes B73-M... 19586775
Listeria monocytogenes IC50 = 13000.0 nM 4.89 Antibacterial activity against leucocin A-sensitive Listeria monocytogenes B73 a... 19586775
Micrococcus luteus IC50 = 22000.0 nM 4.66 Antibacterial activity against Micrococcus luteus NCTC 8340 after 16 hrs by brot... 19586775

Literature References

PubMed DOI Target Context # Activities
33991963 10.1016/j.ejmech.2021.113488 Cell membrane 7
19586775 10.1016/j.bmc.2009.06.029 Listeria monocytogenes 7
29140694 10.1021/acs.jmedchem.7b00953 Staphylococcus aureus 4
29140694 10.1021/acs.jmedchem.7b00953 Candida albicans 3
33991963 10.1016/j.ejmech.2021.113488 Staphylococcus aureus 3
14584933 10.1021/jm0341352 Bacillus subtilis 2
29140694 10.1021/acs.jmedchem.7b00953 Pseudomonas aeruginosa 2
19586775 10.1016/j.bmc.2009.06.029 Micrococcus luteus 2
33991963 10.1016/j.ejmech.2021.113488 Escherichia coli 2
19281223 10.1021/jm801577r Bacillus subtilis 2
17728134 10.1016/j.bmc.2007.08.007 Enterococcus faecalis 2
17728134 10.1016/j.bmc.2007.08.007 Staphylococcus aureus 2
33991963 10.1016/j.ejmech.2021.113488 Lipid bilayer 2
17728134 10.1016/j.bmc.2007.08.007 Escherichia coli 1
17728134 10.1016/j.bmc.2007.08.007 Staphylococcus epidermidis 1
17728134 10.1016/j.bmc.2007.08.007 Bacillus subtilis 1
17547386 10.1021/jm070282e ADMET 1
17547386 10.1021/jm070282e Staphylococcus epidermidis 1
17547386 10.1021/jm070282e Enterococcus faecalis 1
17547386 10.1021/jm070282e Bacillus subtilis 1

Data from ChEMBL 36 via Core Engine