Compound Detail
CHEMBL408700
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Basic Information
| ChEMBL ID | CHEMBL408700 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CTLUQIBJZYPRJB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
341.3
MW (Da)
3.92
ALogP
1
HBA
1
HBD
43.1
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 CHEMBL4305 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-st... | 18232633 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18232633 | 10.1021/jm070663s | Intermediate conductance calcium-activated potassium channel protein 4 | 1 |
| 18232633 | 10.1021/jm070663s | Liver | 1 |
| 18232633 | 10.1021/jm070663s | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine