Compound Detail
CHEMBL4088567
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4088567 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OOINUTDVCAIHNI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
426.9
MW (Da)
2.91
ALogP
6
HBA
1
HBD
96.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 100.0 | nM | 7.0 | Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs ... | 28541707 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28541707 | 10.1021/acs.jmedchem.7b00618 | Liver | 3 |
| 28541707 | 10.1021/acs.jmedchem.7b00618 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2 |
| 28541707 | 10.1021/acs.jmedchem.7b00618 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine