Compound Detail
CHEMBL4098415
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Basic Information
| ChEMBL ID | CHEMBL4098415 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GTCGOWXPZOMCOM-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
495.4
MW (Da)
5.20
ALogP
5
HBA
1
HBD
85.6
PSA (Ų)
0.46
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 6.24 | 6.24 | 573.0 | 1 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | EC50 | 5.71 | 5.71 | 1963.0 | 1 |
| Peroxisome proliferator-activated receptor delta CHEMBL3979 | EC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 573.0 | nM | 6.24 | Transactivation of human GAL4-fused PPARgamma LBD expressed in African green mon... | 29446942 |
| Peroxisome proliferator-activated receptor alpha | EC50 | = | 1963.0 | nM | 5.71 | Transactivation of human GAL4-fused PPARalpha LBD expressed in African green mon... | 29446942 |
| Peroxisome proliferator-activated receptor delta | EC50 | = | 2100.0 | nM | 5.68 | Transactivation of human GAL4-fused PPARdelta LBD expressed in African green mon... | 29446942 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29446942 | 10.1021/acs.jmedchem.7b01285 | Peroxisome proliferator-activated receptor alpha | 2 |
| 29446942 | 10.1021/acs.jmedchem.7b01285 | Peroxisome proliferator-activated receptor delta | 2 |
| 29446942 | 10.1021/acs.jmedchem.7b01285 | Peroxisome proliferator-activated receptor gamma | 2 |
Data from ChEMBL 36 via Core Engine