Compound Detail
CHEMBL4099066
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CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(/N=N\c2ccc(-c3ccccc3)cc2)c1)[C@@H](C)O)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Basic Information
| ChEMBL ID | CHEMBL4099066 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IVOQASYQSURFBD-OTLXPWEOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
650.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.54 | 6.84 | 29.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 29.0 | nM | 7.54 | Inhibition of chymotrypsin-like activity of 20S proteasome in rabbit 20S proteas... | 28642029 |
| Unchecked | IC50 | = | 727.0 | nM | 6.14 | Inhibition of caspase-like activity of 20S proteasome in rabbit 20S proteasome p... | 28642029 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28642029 | 10.1016/j.bmc.2017.06.011 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine