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Compound Detail

CHEMBL4099865

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CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)CN)C(=O)N[C@@H](CSSC[C@H](C(N)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N2

Basic Information

ChEMBL ID CHEMBL4099865
Phase Preclinical
Structure Type MOL
InChI Key MXSUSAVIZSMZTP-YZXASESUSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

1311.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C54H82N14O16S4
MW 1311.60

Activity Summary

IC50 2 meas. best 8.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nicotinic acetylcholine receptor alpha6/alpha3/beta4
CHEMBL3137276
IC50 8.81 8.81 1.5 1
Neuronal acetylcholine receptor; alpha3/beta4
CHEMBL1907593
IC50 7.56 7.56 27.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28603989 10.1021/acs.jmedchem.7b00546 Neuronal acetylcholine receptor; alpha3/beta4 1
28603989 10.1021/acs.jmedchem.7b00546 Nicotinic acetylcholine receptor alpha6/alpha3/beta4 1
28603989 10.1021/acs.jmedchem.7b00546 Unchecked 1

Data from ChEMBL 36 via Core Engine