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Compound Detail

CHEMBL4099875

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C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@H]1O

Basic Information

ChEMBL ID CHEMBL4099875
Phase Preclinical
Structure Type MOL
InChI Key GMRQFYUYWCNGIN-PEJFXWBPSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

416.6
MW (Da)
5.70
ALogP
3
HBA
3
HBD
60.7
PSA (Ų)
0.52
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C27H44O3
MW 416.65
Aromatic Rings 0
Heavy Atoms 30
NP-Likeness 2.65

Activity Summary

EC50 1 meas. best 9.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vitamin D3 receptor A
CHEMBL3217399
EC50 9.85 9.85 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28399453 10.1016/j.ejmech.2017.03.081 Vitamin D3 receptor 2
28399453 10.1016/j.ejmech.2017.03.081 Vitamin D3 receptor A 2

Data from ChEMBL 36 via Core Engine