Compound Detail

CHEMBL4100408

TP-024n

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Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)nc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4100408
Name	TP-024n
Phase	Preclinical
Structure Type	MOL
InChI Key	LEEQPBKUBIMCLS-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

377.4

MW (Da)

4.22

ALogP

HBA

HBD

68.9

PSA (Å²)

0.74

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL4689842	HEK-293T	345
-	10.6019/CHEMBL4689842	U2OS	344
-	10.6019/CHEMBL4689842	Fibroblast	344
-	10.6019/CHEMBL4507305	Tyrosine-protein kinase ABL1	15
-	10.6019/CHEMBL5724558	Colon cancer organoid	12
-	10.6019/CHEMBL4507305	Epidermal growth factor receptor	12
-	10.6019/CHEMBL5674860	Colon cancer organoid	12
-	10.6019/CHEMBL4507305	Receptor-type tyrosine-protein kinase FLT3	11
-	10.6019/CHEMBL4507305	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	10
-	10.6019/CHEMBL4507305	Mast/stem cell growth factor receptor Kit	9
-	10.6019/CHEMBL4507305	Unchecked	8
-	10.6019/CHEMBL5608141	Colon cancer organoid	6
-	10.1158/2159-8290.CD-23-0050	Colon cancer organoid	5
-	10.6019/CHEMBL4507305	Proto-oncogene tyrosine-protein kinase receptor Ret	4
-	10.6019/CHEMBL4507305	Hepatocyte growth factor receptor	3
-	10.6019/CHEMBL4507305	ALK tyrosine kinase receptor	3
-	10.6019/CHEMBL4507305	Ribosomal protein S6 kinase alpha-5	2
-	10.6019/CHEMBL4507305	Tyrosine-protein kinase JAK1	2
-	10.6019/CHEMBL4507305	Ribosomal protein S6 kinase alpha-4	2
-	10.6019/CHEMBL4507305	Macrophage colony-stimulating factor 1 receptor	2

Data from ChEMBL 36 via Core Engine