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Compound Detail

CHEMBL4101681

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Cc1n[nH]c2ccc(-c3cc(N[C@@H](C)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4101681
Phase Preclinical
Structure Type MOL
InChI Key UTUIDOAJVKTSNZ-INIZCTEOSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

455.0
MW (Da)
7.13
ALogP
4
HBA
3
HBD
73.8
PSA (Ų)
0.26
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H23ClN4O
MW 454.96
Aromatic Rings 5
Heavy Atoms 33
NP-Likeness -1.05

Literature References

PubMed DOI Target Context # Activities
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 2 1
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 1 1
28714692 10.1021/acs.jmedchem.7b00076 Fibroblast growth factor receptor 3 1

Data from ChEMBL 36 via Core Engine