Compound Detail
CHEMBL410325
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Basic Information
| ChEMBL ID | CHEMBL410325 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PNNHQGDWIIUMFS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
424.5
MW (Da)
4.82
ALogP
5
HBA
1
HBD
87.7
PSA (Ų)
0.46
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor A CHEMBL329 | IC50 | 7.02 | 7.02 | 95.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor A | IC50 | = | 95.0 | nM | 7.02 | Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic mem... | 18318468 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18318468 | 10.1021/jm7011563 | Type-1 angiotensin II receptor A | 1 |
| 18318468 | 10.1021/jm7011563 | Caco-2 | 1 |
Data from ChEMBL 36 via Core Engine