Compound Detail
CHEMBL4103922
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CC(C)(C)N1CCC(N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cccc(C(F)(F)F)c2)CC1
Basic Information
| ChEMBL ID | CHEMBL4103922 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZKBXBZXBCLGRH-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
2
PK Parameters
6
Publications
0
Known Names
Molecular Properties
477.5
MW (Da)
5.73
ALogP
4
HBA
1
HBD
54.0
PSA (Ų)
0.61
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.58
EC50 1 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 CHEMBL4523603 | IC50 | 6.58 | 6.52 | 260.0 | 2 |
| DCN1-like protein 1 CHEMBL4105838 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
| DCN1-like protein 1 CHEMBL4105838 | EC50 | 6.43 | 6.43 | 370.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 434.0 | mL.min-1.kg-1 | Mus musculus |
| T1/2 | 0.124 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 | IC50 | = | 260.0 | nM | 6.58 | TR-Fret Assay: The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-F... | - |
| DCN1-like protein 1 | IC50 | = | 310.0 | nM | 6.51 | Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of pr... | 29547696 |
| DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 | IC50 | = | 346.0 | nM | 6.46 | TR-Fret Assay: The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-F... | - |
| DCN1-like protein 1 | EC50 | = | 370.0 | nM | 6.43 | Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in tr... | 29547696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29547696 | 10.1021/acs.jmedchem.7b01277 | DCN1-like protein 1 | 3 |
| 29547693 | 10.1021/acs.jmedchem.7b01282 | Liver | 2 |
| 29547696 | 10.1021/acs.jmedchem.7b01277 | No relevant target | 2 |
| 29547696 | 10.1021/acs.jmedchem.7b01277 | BJ | 1 |
| 29547696 | 10.1021/acs.jmedchem.7b01277 | HCC95 | 1 |
| 29547696 | 10.1021/acs.jmedchem.7b01277 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine