Compound Detail
CHEMBL4116728
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Basic Information
| ChEMBL ID | CHEMBL4116728 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YGJWJMZUNWDBHI-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
410.9
MW (Da)
3.03
ALogP
7
HBA
1
HBD
109.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 9.0 | 8.76 | 1.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 1.0 | nM | 9.0 | ADP-Glo Format PI3K Assay: The ADP-Glo format PI3K assays were performed in Prox... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 3.0 | nM | 8.52 | ADP-Glo Format PI3K Assay: The ADP-Glo format PI3K assays were performed in Prox... | - |
Data from ChEMBL 36 via Core Engine