Compound Detail
CHEMBL4125955
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Basic Information
| ChEMBL ID | CHEMBL4125955 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ALHYYNUQHJPBGH-VIFPVBQESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
359.8
MW (Da)
3.71
ALogP
4
HBA
1
HBD
75.4
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 6.8 | 6.8 | 158.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 158.49 | nM | 6.8 | Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) usi... | 29852070 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29852070 | 10.1021/acs.jmedchem.8b00447 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2 |
| 29852070 | 10.1021/acs.jmedchem.8b00447 | PI3-kinase p110-alpha/p85-alpha | 1 |
Data from ChEMBL 36 via Core Engine