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Compound Detail

CHEMBL412645

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COc1cc([C@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)NCC(=O)N23)cc(OC)c1O

Basic Information

ChEMBL ID CHEMBL412645
Phase Preclinical
Structure Type MOL
InChI Key HTPGHTCBAMDAAS-YWZLYKJASA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

407.4
MW (Da)
1.86
ALogP
5
HBA
3
HBD
103.9
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H21N3O5
MW 407.43
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness 0.26

Literature References

PubMed DOI Target Context # Activities
10780915 10.1021/jm9905662 3Y1 cell line 3
10780915 10.1021/jm9905662 Panel leukemia (Carcinoma cell lines) 1
10780915 10.1021/jm9905662 NSO 1
10780915 10.1021/jm9905662 Colon cell 1
10780915 10.1021/jm9905662 CNS cell 1
10780915 10.1021/jm9905662 Melanoma cell 1
10780915 10.1021/jm9905662 Ovarian carcinoma cell 1
10780915 10.1021/jm9905662 Renal cell 1
10780915 10.1021/jm9905662 Prostate cell 1
10780915 10.1021/jm9905662 Breast carcinoma cell 1

Data from ChEMBL 36 via Core Engine