Compound Detail
CHEMBL4128112
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL4128112 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXWFCECUCFJATL-JYPKCNOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
3228.7
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL1784 | IC50 | 5.95 | 5.95 | 1132.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | IC50 | = | 1132.3 | nM | 5.95 | Displacement of [125I]GLP-1 from human GLP1R expressed in HEK293 cell membranes ... | 29879354 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29879354 | 10.1021/acs.jmedchem.8b00292 | Glucagon-like peptide 1 receptor | 2 |
| 29879354 | 10.1021/acs.jmedchem.8b00292 | Gastric inhibitory polypeptide receptor | 1 |
| 29879354 | 10.1021/acs.jmedchem.8b00292 | Glucagon receptor | 1 |
Data from ChEMBL 36 via Core Engine