Compound Detail
CHEMBL413532
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Basic Information
| ChEMBL ID | CHEMBL413532 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCJYJJSGANKJAI-UHLUBPPHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
394.2
MW (Da)
3.17
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 2, Kir6.2 CHEMBL2095198 | EC50 | 8.74 | 8.74 | 1.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 2, Kir6.2 | EC50 | = | 1.82 | nM | 8.74 | Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cel... | 17154517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17154517 | 10.1021/jm060549u | Sulfonylurea receptor 2, Kir6.2 | 2 |
Data from ChEMBL 36 via Core Engine