Compound Detail
CHEMBL4161696
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Basic Information
| ChEMBL ID | CHEMBL4161696 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BQJCZFWTKLQWKH-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
441.5
MW (Da)
3.67
ALogP
7
HBA
1
HBD
109.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nuclear receptor ROR-gamma CHEMBL1741186 | IC50 | 7.52 | 7.46 | 30.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Fu | 0.0009 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nuclear receptor ROR-gamma | IC50 | = | 30.0 | nM | 7.52 | Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)t... | 30095900 |
| Nuclear receptor ROR-gamma | IC50 | = | 40.0 | nM | 7.4 | Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to ... | 30095900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30095900 | 10.1021/acs.jmedchem.8b00783 | ADMET | 5 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | Nuclear receptor ROR-gamma | 4 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | No relevant target | 2 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | Caco-2 | 1 |
Data from ChEMBL 36 via Core Engine