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Compound Detail

CHEMBL416287

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C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@H](C(=O)O)NC(=O)[C@H]2CCCN2C1=O

Basic Information

ChEMBL ID CHEMBL416287
Phase Preclinical
Structure Type BOTH
InChI Key KSMDTXOOAPSTEL-HFYOPZJCSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

936.0
MW (Da)
-5.43
ALogP
13
HBA
13
HBD
398.2
PSA (Ų)
0.10
QED
3
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C41H53N13O13
MW 935.95
Aromatic Rings 3
Heavy Atoms 67
NP-Likeness 0.98

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)00296-5 Endothelin receptor type B 1

Data from ChEMBL 36 via Core Engine