Compound Detail
CHEMBL4171446
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Basic Information
| ChEMBL ID | CHEMBL4171446 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IVVGUPBQCNZMHZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
371.4
MW (Da)
3.22
ALogP
6
HBA
2
HBD
92.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Egl nine homolog 1 CHEMBL5697 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | IC50 | = | 0.7 | nM | 9.15 | Inhibition of FLAG- tagged full length HIF-PHD2 (unknown origin) expressed in ba... | 29712435 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29712435 | 10.1021/acs.jmedchem.7b01686 | Egl nine homolog 1 | 1 |
Data from ChEMBL 36 via Core Engine