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Compound Detail

CHEMBL4174622

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Cl.NCc1ccc(O)c2ccccc12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4174622
Phase Preclinical
Structure Type MOL
InChI Key PYLFDMFSGRNMLS-UHFFFAOYSA-N
Parent Compound CHEMBL4300198
Active Moiety CHEMBL4300198
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

173.2
MW (Da)
2.00
ALogP
2
HBA
2
HBD
46.2
PSA (Ų)
0.69
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H12ClNO
MW 209.68
Aromatic Rings 2
Heavy Atoms 13
NP-Likeness 0.35

Activity Summary

EC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
28527406 10.1016/j.ejmech.2017.05.015 Histone acetyltransferase KAT8 2
28527406 10.1016/j.ejmech.2017.05.015 Histone acetyltransferase KAT2B 1
28527406 10.1016/j.ejmech.2017.05.015 No relevant target 1
28527406 10.1016/j.ejmech.2017.05.015 Histone acetyltransferase p300 1

Data from ChEMBL 36 via Core Engine