Compound Detail
CHEMBL4176537
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Basic Information
| ChEMBL ID | CHEMBL4176537 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CDOLAAMXGRJGPL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
380.7
MW (Da)
4.13
ALogP
5
HBA
1
HBD
89.3
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 CHEMBL1744522 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 | IC50 | = | 16.0 | nM | 7.8 | Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 ... | 30289716 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30289716 | 10.1021/acs.jmedchem.8b01196 | Endothelial PAS domain-containing protein 1 | 1 |
Data from ChEMBL 36 via Core Engine