Compound Detail
CHEMBL4176822
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Basic Information
| ChEMBL ID | CHEMBL4176822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHPSXPWLHPRNOB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
492.6
MW (Da)
5.36
ALogP
6
HBA
1
HBD
85.4
PSA (Ų)
0.34
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nuclear receptor ROR-gamma CHEMBL1741186 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Fu | 0.0003 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nuclear receptor ROR-gamma | IC50 | = | 20.0 | nM | 7.7 | Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)t... | 30095900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30095900 | 10.1021/acs.jmedchem.8b00783 | Unchecked | 3 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | Nuclear receptor ROR-gamma | 3 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | No relevant target | 2 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | ADMET | 1 |
| 30095900 | 10.1021/acs.jmedchem.8b00783 | Hepatocyte | 1 |
Data from ChEMBL 36 via Core Engine