Compound Detail
CHEMBL419458
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Basic Information
| ChEMBL ID | CHEMBL419458 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QGCUYXCPMZGMFQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
347.8
MW (Da)
4.41
ALogP
5
HBA
1
HBD
63.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.39 | 6.39 | 410.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 6.12 | 6.12 | 760.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 410.0 | nM | 6.39 | Inhibitory activity against kinase domain containing receptor (KDR/VEGFR2) | 10882357 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 760.0 | nM | 6.12 | Inhibitory activity against Flt-kinase | 10882357 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10882357 | 10.1021/jm9909443 | Vascular endothelial growth factor receptor 1 | 1 |
| 10882357 | 10.1021/jm9909443 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine