Compound Detail

CHEMBL419903

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O=C(Nc1n[nH]c2cc(-c3ccc(F)cc3)ccc12)C1CC1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL419903
Phase	Preclinical
Structure Type	MOL
InChI Key	FXJZPZMEETZHRB-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

295.3

MW (Da)

3.72

ALogP

HBA

HBD

57.8

PSA (Å²)

0.77

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL1961873	Tyrosine-protein kinase ABL1	14
-	10.6019/CHEMBL1961873	Epidermal growth factor receptor	10
-	10.6019/CHEMBL1961873	Mast/stem cell growth factor receptor Kit	8
-	10.6019/CHEMBL1961873	Platelet-derived growth factor receptor alpha	8
-	10.6019/CHEMBL1961873	Proto-oncogene tyrosine-protein kinase receptor Ret	6
-	10.6019/CHEMBL1961873	Cyclin-dependent kinase 2	4
-	10.6019/CHEMBL1961873	Serine/threonine-protein kinase B-raf	4
-	10.6019/CHEMBL1961873	Leucine-rich repeat serine/threonine-protein kinase 2	4
-	10.6019/CHEMBL1961873	Tyrosine-protein kinase Lyn	4
-	10.6019/CHEMBL1961873	Protein kinase C beta type	4
-	10.6019/CHEMBL1961873	Receptor-type tyrosine-protein kinase FLT3	4
-	10.6019/CHEMBL1961873	Ribosomal protein S6 kinase alpha-4	2
-	10.6019/CHEMBL1961873	Ribosomal protein S6 kinase beta-1	2
-	10.6019/CHEMBL1961873	Ribosomal protein S6 kinase alpha-5	2
-	10.6019/CHEMBL1961873	cAMP-dependent protein kinase catalytic subunit alpha	2
-	10.6019/CHEMBL1961873	Protein kinase C alpha type	2
-	10.6019/CHEMBL1961873	Rhodopsin kinase GRK7	2
-	10.6019/CHEMBL1961873	G protein-coupled receptor kinase 6	2
-	10.6019/CHEMBL2007661	Serine/threonine-protein kinase TBK1	2
-	10.6019/CHEMBL1961873	RAC-alpha serine/threonine-protein kinase	2

Data from ChEMBL 36 via Core Engine