Compound Detail
CHEMBL4203778
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Basic Information
| ChEMBL ID | CHEMBL4203778 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OFGGGRQZSDQDFW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
3
Publications
0
Known Names
Molecular Properties
340.5
MW (Da)
2.77
ALogP
4
HBA
1
HBD
49.6
PSA (Ų)
0.91
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | EC50 | 7.47 | 7.47 | 34.2 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | - | - | Rattus norvegicus |
| CL | - | - | Rattus norvegicus |
| Cmax | - | - | Rattus norvegicus |
| F | - | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | EC50 | = | 34.2 | nM | 7.47 | Agonist activity at recombinant human 5-HT4E receptor expressed in CHO cells ass... | 29763304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29763304 | 10.1021/acs.jmedchem.8b00457 | Rattus norvegicus | 4 |
| 29763304 | 10.1021/acs.jmedchem.8b00457 | ADMET | 3 |
| 29763304 | 10.1021/acs.jmedchem.8b00457 | 5-hydroxytryptamine receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine