Compound Detail
CHEMBL4204214
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Basic Information
| ChEMBL ID | CHEMBL4204214 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOTALVKQMXVWDC-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
171.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.4
Ki 1 meas. best 4.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase N CHEMBL1907 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Cytosol aminopeptidase CHEMBL3965 | Ki | 4.05 | 4.05 | 90000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | IC50 | = | 40.0 | nM | 7.4 | Inhibition of APN (unknown origin) | 29630364 |
| Cytosol aminopeptidase | Ki | = | 90000.0 | nM | 4.05 | Inhibition of LAP (unknown origin) | 29630364 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29630364 | 10.1021/acs.jmedchem.7b00782 | Cytosol aminopeptidase | 1 |
| 29630364 | 10.1021/acs.jmedchem.7b00782 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine