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Compound Detail

CHEMBL4205070

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CO[C@H](C)O[C@H]1[C@@H]2[C@@H](C)[C@@H](O)C[C@H](O)[C@@]2(C)[C@@H](O)[C@H](OC(C)=O)C2=C(C)[C@@H](OC(C)=O)C[C@]1(O)C2(C)C

Basic Information

ChEMBL ID CHEMBL4205070
Phase Preclinical
Structure Type MOL
InChI Key COEADASEFNUEQJ-WBRSTNQWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

528.6
MW (Da)
1.46
ALogP
10
HBA
4
HBD
152.0
PSA (Ų)
0.23
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C27H44O10
MW 528.64
Aromatic Rings 0
Heavy Atoms 37
NP-Likeness 2.72

Activity Summary

IC50 1 meas. best 4.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.01 4.01 97500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 97500.0 nM 4.01 Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alp... 28240909

Literature References

PubMed DOI Target Context # Activities
28240909 10.1021/acs.jnatprod.7b00006 Unchecked 1
28240909 10.1021/acs.jnatprod.7b00006 HeLa 1

Data from ChEMBL 36 via Core Engine