Compound Detail
CHEMBL4205598
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Basic Information
| ChEMBL ID | CHEMBL4205598 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KOWZZWZCSJUIGO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
420.4
MW (Da)
4.86
ALogP
6
HBA
1
HBD
77.3
PSA (Ų)
0.45
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 2.38 | nM | 8.62 | Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in E... | 30148362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30148362 | 10.1021/acs.jmedchem.8b01209 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine