Compound Detail
CHEMBL4208308
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Basic Information
| ChEMBL ID | CHEMBL4208308 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TYZFQSLJTWPSDS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
302.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 CHEMBL6032 | IC50 | 6.35 | 6.35 | 450.0 | 1 |
| Histone-lysine N-methyltransferase EHMT1 CHEMBL6031 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 | IC50 | = | 450.0 | nM | 6.35 | Inhibition of wild type recombinant human histone lysine methyltransferase G9a (... | 29519735 |
| Histone-lysine N-methyltransferase EHMT1 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of wild type recombinant human histone lysine methyltransferase GLP (... | 29519735 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29519735 | 10.1016/j.bmcl.2018.02.043 | Histone-lysine N-methyltransferase EHMT2 | 4 |
| 29519735 | 10.1016/j.bmcl.2018.02.043 | Histone-lysine N-methyltransferase EHMT1 | 4 |
Data from ChEMBL 36 via Core Engine