Compound Detail
CHEMBL4208746
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Basic Information
| ChEMBL ID | CHEMBL4208746 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MOJLDADXMLCYRL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
431.9
MW (Da)
3.69
ALogP
5
HBA
2
HBD
104.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 7.17 | 7.17 | 68.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 68.0 | nM | 7.17 | Inhibition of recombinant full length His-tagged human PI3K p110gamma expressed ... | 28835805 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28835805 | 10.1021/acsmedchemlett.7b00222 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine