Compound Detail
CHEMBL4210135
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C#CCCOc1ccc(C(=O)c2ccc(CCC(=O)N3CCC(CCNCc4cc(-c5cc(-c6cccc(C(F)(F)F)c6)ccc5Oc5ccc(S(=O)(=O)Nc6ncns6)cc5C#N)ccn4)CC3)cc2)cc1
Basic Information
| ChEMBL ID | CHEMBL4210135 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QWYRZICRFITVGK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1024.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 10.0 | 10.0 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 0.1 | nM | 10.0 | Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiolo... | 29029933 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29029933 | 10.1016/j.bmcl.2017.09.056 | Sodium channel protein type 9 subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine