Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4211195

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COCCOCOc1ccc(-c2ccc(C(=O)O)c(OC)c2)cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C

Basic Information

ChEMBL ID CHEMBL4211195
Phase Preclinical
Structure Type MOL
InChI Key ZPBSAZORQULIPL-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names

Molecular Properties

518.6
MW (Da)
7.08
ALogP
5
HBA
1
HBD
74.2
PSA (Ų)
0.23
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H38O6
MW 518.65
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness 0.17

Activity Summary

EC50 1 meas. best 6.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor gamma
CHEMBL2003
EC50 6.78 6.78 168.0 1

Pharmacokinetic Data

Parameter Value Units Species
Fu 0.0001 - Not specified

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29706423 10.1016/j.bmcl.2018.04.036 Retinoic acid receptor gamma 1
29706423 10.1016/j.bmcl.2018.04.036 ADMET 1

Data from ChEMBL 36 via Core Engine