Compound Detail
CHEMBL4213835
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CC(=O)O[C@@H]1CC[C@]2(C)[C@H](CC[C@]3(CNc4cccc(F)c4)O[C@H](C4=CCOC4=O)C[C@H]32)[C@]1(C)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL4213835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FIZOICCCVXWANU-GCXCVHSYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
740.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.35 | 4.35 | 44840.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 44840.0 | nM | 4.35 | Cytotoxicity against rat ASK cells assessed as reduction in cell viability by SR... | 28755636 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28755636 | 10.1016/j.ejmech.2017.07.035 | HT-29 | 1 |
| 28755636 | 10.1016/j.ejmech.2017.07.035 | KB | 1 |
| 28755636 | 10.1016/j.ejmech.2017.07.035 | P388 | 1 |
| 28755636 | 10.1016/j.ejmech.2017.07.035 | MCF7 | 1 |
| 28755636 | 10.1016/j.ejmech.2017.07.035 | A549 | 1 |
| 28755636 | 10.1016/j.ejmech.2017.07.035 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine