Compound Detail
CHEMBL4216516
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Basic Information
| ChEMBL ID | CHEMBL4216516 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XTKNHHMMUHAGKV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
1.32
ALogP
7
HBA
4
HBD
147.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 6.78 | 6.78 | 166.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | Ki | = | 166.0 | nM | 6.78 | Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured ove... | 30130401 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30130401 | 10.1021/acs.jmedchem.8b00838 | Urokinase-type plasminogen activator | 1 |
Data from ChEMBL 36 via Core Engine