Compound Detail
CHEMBL4217087
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Basic Information
| ChEMBL ID | CHEMBL4217087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JHXDJXMQZRAMSL-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
492.7
MW (Da)
5.21
ALogP
7
HBA
0
HBD
54.2
PSA (Ų)
0.38
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 CHEMBL6032 | IC50 | 8.1 | 7.065 | 8.0 | 2 |
| DNA (cytosine-5)-methyltransferase 1 CHEMBL1993 | IC50 | 5.88 | 5.55 | 1320.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of G9a (unknown origin) | 34052677 |
| Histone-lysine N-methyltransferase EHMT2 | IC50 | = | 935.0 | nM | 6.03 | Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr ... | 29890830 |
| DNA (cytosine-5)-methyltransferase 1 | IC50 | = | 1320.0 | nM | 5.88 | Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substr... | 29890830 |
| DNA (cytosine-5)-methyltransferase 1 | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of DNMT1 (unknown origin) | 34052677 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29890830 | 10.1021/acs.jmedchem.7b01925 | Histone-lysine N-methyltransferase EHMT2 | 1 |
| 29890830 | 10.1021/acs.jmedchem.7b01925 | DNA (cytosine-5)-methyltransferase 1 | 1 |
| 34052677 | 10.1016/j.ejmech.2021.113555 | DNA (cytosine-5)-methyltransferase 1 | 1 |
| 34052677 | 10.1016/j.ejmech.2021.113555 | Histone-lysine N-methyltransferase EHMT2 | 1 |
Data from ChEMBL 36 via Core Engine