Compound Detail
CHEMBL4217268
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Basic Information
| ChEMBL ID | CHEMBL4217268 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KHEKCWKGNNYJEO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
388.9
MW (Da)
4.03
ALogP
5
HBA
2
HBD
84.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.83 | 5.83 | 1491.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 1491.0 | nM | 5.83 | Inhibition of recombinant full length His-tagged human PI3K p110gamma expressed ... | 28835805 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28835805 | 10.1021/acsmedchemlett.7b00222 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine