Compound Detail
CHEMBL4225378
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Basic Information
| ChEMBL ID | CHEMBL4225378 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DHSLBHAALNFVSZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
367.5
MW (Da)
2.57
ALogP
7
HBA
3
HBD
96.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of human PIM1 | 29559278 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29559278 | 10.1016/j.bmcl.2018.03.018 | Casein kinase II subunit alpha | 1 |
| 29559278 | 10.1016/j.bmcl.2018.03.018 | Serine/threonine-protein kinase pim-1 | 1 |
| 29559278 | 10.1016/j.bmcl.2018.03.018 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine