Compound Detail
CHEMBL4247074
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Basic Information
| ChEMBL ID | CHEMBL4247074 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DTBCGYKPZMEEKN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
339.5
MW (Da)
4.50
ALogP
3
HBA
1
HBD
37.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 CHEMBL2476 | EC50 | 7.47 | 7.47 | 34.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | EC50 | = | 34.0 | nM | 7.47 | Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after ... | 30061030 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30061030 | 10.1016/j.bmcl.2018.05.019 | Potassium voltage-gated channel subfamily KQT member 2 | 4 |
Data from ChEMBL 36 via Core Engine