Compound Detail
CHEMBL426160
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Basic Information
| ChEMBL ID | CHEMBL426160 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NNSUHZUFQXKNRA-HUUCEWRRSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
469.2
MW (Da)
3.79
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 2, Kir6.2 CHEMBL2095198 | EC50 | 7.57 | 6.76 | 26.9 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 2, Kir6.2 | EC50 | = | 26.92 | nM | 7.57 | Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cel... | 17154517 |
| Sulfonylurea receptor 2, Kir6.2 | EC50 | = | 75.86 | nM | 7.12 | Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cel... | 17154517 |
| Sulfonylurea receptor 2, Kir6.2 | EC50 | = | 229.09 | nM | 6.64 | Activity against pig bladder KATP channel opening assessed as ability to relax f... | 17154517 |
| Sulfonylurea receptor 2, Kir6.2 | EC50 | = | 1949.84 | nM | 5.71 | Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cel... | 17154517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17154517 | 10.1021/jm060549u | Sulfonylurea receptor 2, Kir6.2 | 8 |
Data from ChEMBL 36 via Core Engine